Life is looking pretty bleak for theater director Caden Cotard (Philip Seymour Hoffman). His wife and daughter have left him, his therapist is more interested in plugging her new book than helping him with his problems, and a strange disease is causing his body to shut down. Caden leaves his home in Schenectady, New York, and heads to New York City, where he gathers a cast of actors and tells them to live their lives within the constructs of a mock-up of the city.