In an unnamed country at an unspecified time, there is a fiercely protected post-apocalyptic wasteland known as The Zone. An illegal guide (Aleksandr Kajdanovsky), whose mutant child suggests unspeakable horrors within The Zone, leads a writer (Anatoliy Solonitsyn) and a scientist (Nikolay Grinko) into the heart of the devastation in search of a mythical place known only as The Room. Anyone who enters The Room will supposedly have any of his earthly desires immediately fulfilled.

A psychologist is sent to a station orbiting a distant planet in order to discover what has caused the crew to go insane.