In Carthage, Mo., former New York-based writer Nick Dunne and his glamorous wife Amy present a portrait of a blissful marriage to the public; when Amy goes missing on the couple's fifth wedding anniversary, Nick becomes the prime suspect in her disappearance; the resulting police pressure and media frenzy cause the Dunnes' image of a happy union to crumble, leading to tantalizing questions about who Nick and Amy truly are.

Disgraced financial reporter Mikael Blomkvist (Daniel Craig) finds a chance to redeem his honor after being hired by wealthy Swedish industrialist Henrik Vanger (Christopher Plummer) to solve the 40-year-old murder of Vanger's niece, Harriet. Vanger believes that Harriet was killed by a member of his own family. Eventually joining Blomkvist on his dangerous quest for the truth is Lisbeth Salander (Rooney Mara), an unusual but ingenious investigator whose fragile trust is not easily won.

Nicholas Van Orton (Michael Douglas) is a successful banker who keeps mostly to himself. When his estranged brother Conrad (Sean Penn) returns on his birthday with an odd gift -- participation in a personalized, real-life game -- Nicholas reluctantly accepts. Initially harmless, the game grows increasingly personal, and Orton begins to fear for his life as he eludes agents from the mysterious game's organizers. With no one left to trust and his money gone, Orton must find answers for himself.