In a distant galaxy, planet Spaceball has depleted its air supply, leaving its citizens reliant on a product called "Perri-Air." In desperation, Spaceball's leader President Skroob (Mel Brooks) orders the evil Dark Helmet (Rick Moranis) to kidnap Princess Vespa (Daphne Zuniga) of oxygen-rich Druidia and hold her hostage in exchange for air. But help arrives for the Princess in the form of renegade space pilot Lone Starr (Bill Pullman) and his half-man, half-dog partner, Barf (John Candy).

In order to ruin a western town, a corrupt politician appoints a black Sheriff, who promptly becomes his most formidable adversary.

Respected medical lecturer Dr. Frederick Frankenstein (Gene Wilder) learns that he has inherited his infamous grandfather's estate in Transylvania. Arriving at the castle, Dr. Frankenstein soon begins to recreate his grandfather's experiments with the help of servants Igor (Marty Feldman), Inga (Teri Garr) and the fearsome Frau Blücher (Cloris Leachman). After he creates his own monster (Peter Boyle), new complications ensue with the arrival of the doctor's fiancée, Elizabeth (Madeline Kahn).